| Louisville Games/Schedule |
| Regular Season |
| Nov. 12, 2021 | Day 4 | Louisville (5) - Arizona (20) | 59-61  |
| Nov. 16, 2021 | Day 8 | Bellarmine - Louisville (5) | 25-82  |
| Nov. 17, 2021 | Day 9 | UT Martin - Louisville (5) | 30-62 |
| Nov. 20, 2021 | Day 12 | Louisville (5) - Washington | 61-53 |
| Nov. 23, 2021 | Day 15 | Louisville (5) - Cal Poly | 72-32 |
| Nov. 28, 2021 | Day 20 | Louisville (5) - Colorado St. | 71-56 |
| Dec. 2, 2021 | Day 24 | Michigan (12) - Louisville (5) | 48-70 |
| Dec. 5, 2021 | Day 27 | Belmont - Louisville (5) | 66-80 |
| Dec. 12, 2021 | Day 34 | Kentucky (16) - Louisville (5) | 58-64 |
| Dec. 16, 2021 | Day 38 | EKU - Louisville (5) | 38-82 |
| Dec. 19, 2021 | Day 41 | Louisville (5) - UConn (6) | 69-64 |
| Dec. 30, 2021 | Day 49 | Boston Coll. - Louisville (5) | 49-79 |
| Jan. 2, 2022 | Day 52 | Louisville (5) - Georgia Tech | 50-48 |
| Jan. 6, 2022 | Day 56 | Pittsburgh - Louisville (5) | 39-81 |
| Jan. 13, 2022 | Day 63 | Syracuse - Louisville (5) | 71-84 |
| Jan. 16, 2022 | Day 66 | Louisville (5) - Boston Coll. | 63-53 |
| Jan. 20, 2022 | Day 70 | Louisville (5) - NC State (3) | 59-68 |
| Jan. 23, 2022 | Day 73 | Wake Forest - Louisville (5) | 60-72 |
| Jan. 27, 2022 | Day 77 | FSU - Louisville (5) | 62-75 |
| Jan. 30, 2022 | Day 80 | Duke - Louisville (5) | 65-77 |
| Feb. 1, 2022 | Day 82 | Louisville (5) - Miami, FL | 69-66 |
| Feb. 3, 2022 | Day 84 | Louisville (5) - Clemson | 93-71 |
| Feb. 6, 2022 | Day 87 | Louisville (5) - Syracuse | 100-64 |
| Feb. 13, 2022 | Day 94 | Notre Dame (22) - Louisville (5) | 47-73 |
| Feb. 17, 2022 | Day 98 | Louisville (5) - UNC (18) | 65-66 |
| Feb. 20, 2022 | Day 101 | Virginia Tech (17) - Louisville (5) | 56-70 |
| Feb. 24, 2022 | Day 105 | Louisville (5) - Pittsburgh | 66-55 |
| Feb. 27, 2022 | Day 108 | Louisville (5) - Notre Dame (22) | 86-64 |
| Mar. 4, 2022 | Day 112 | Miami, FL - Louisville (5) | 61-59 |
| National Tournament Day 1 |
| Mar. 18, 2022 | Day 122 | Albany - Louisville (5) | 51-83 |
| National Tournament Day 2 |
| Mar. 20, 2022 | Day 123 | Gonzaga - Louisville (5) | 59-68 |
| National Tournament Day 3 |
| Mar. 26, 2022 | Day 124 | Tennessee (19) - Louisville (5) | 64-76 |
| Regional Finals |
| Mar. 28, 2022 | Day 125 | Michigan (12) - Louisville (5) | 50-62 |
| Final Four |
| Apr. 1, 2022 | Day 126 | Louisville (5) - S.Carolina (1) | 59-72 |
