| Louisville Games/Schedule |
| Regular Season |
| Nov. 6, 2018 | Round 1 | Louisville (5) - W.Kentucky | 102-80 |
| Nov. 9, 2018 | Round 4 | Louisville (5) - Chattanooga | 75-49 |
| Nov. 19, 2018 | Round 14 | Louisville (5) - Boise St. | 74-55 |
| Nov. 23, 2018 | Round 18 | Arizona St. (22) - Louisville (5) | 56-58 |
| Nov. 24, 2018 | Round 19 | Louisville (5) - Hartford | 86-69 |
| Nov. 26, 2018 | Round 21 | Miami, OH - Louisville (5) | 73-95 |
| Nov. 29, 2018 | Round 24 | Nebraska - Louisville (5) | 68-85 |
| Dec. 2, 2018 | Round 27 | Tennessee St. - Louisville (5) | 52-107 |
| Dec. 4, 2018 | Round 29 | Tenn-Martin - Louisville (5) | 62-102 |
| Dec. 9, 2018 | Round 34 | Kentucky (17) - Louisville (5) | 75-80 |
| Dec. 15, 2018 | Round 39 | N.Kentucky - Louisville (5) | 59-92 |
| Dec. 20, 2018 | Round 44 | Louisville (5) - Cent.Michigan | 72-68 |
| Jan. 3, 2019 | Round 54 | N.Carolina - Louisville (5) | 66-73 |
| Jan. 6, 2019 | Round 57 | Louisville (5) - Duke | 73-51 |
| Jan. 10, 2019 | Round 61 | Louisville (5) - Notre Dame (3) | 68-82 |
| Jan. 13, 2019 | Round 64 | Georgia Tech - Louisville (5) | 44-61 |
| Jan. 17, 2019 | Round 68 | Virginia - Louisville (5) | 43-91 |
| Jan. 20, 2019 | Round 71 | Louisville (5) - Wake Forest | 73-49 |
| Jan. 24, 2019 | Round 75 | Louisville (5) - Florida St. (25) | 68-49 |
| Jan. 27, 2019 | Round 78 | Pittsburgh - Louisville (5) | 42-70 |
| Jan. 31, 2019 | Round 82 | Connecticut (2) - Louisville (5) | 69-78 |
| Feb. 2, 2019 | Round 84 | Louisville (5) - Clemson | 76-44 |
| Feb. 7, 2019 | Round 89 | Syracuse (12) - Louisville (5) | 51-76 |
| Feb. 10, 2019 | Round 92 | Louisville (5) - Virginia Tech | 72-63 |
| Feb. 17, 2019 | Round 99 | Miami, FL (19) - Louisville (5) | 79-73 |
| Feb. 21, 2019 | Round 103 | Louisville (5) - Virginia | 71-49 |
| Feb. 24, 2019 | Round 106 | Boston Coll. - Louisville (5) | 51-87 |
| Feb. 28, 2019 | Round 110 | NC State (10) - Louisville (5) | 62-92 |
| Mar. 3, 2019 | Round 113 | Louisville (5) - Pittsburgh | 67-40 |
| Mar. 8, 2019 | Round 118 | Clemson - Louisville (5) | 67-75 |
| Mar. 9, 2019 | Round 119 | NC State (10) - Louisville (5) | 68-78 |
| Mar. 10, 2019 | Round 120 | Louisville (5) - Notre Dame (3) | 79-99 |
| National Tournament Round 1 |
| Mar. 22, 2019 | Round 128 | Robert Morris - Louisville (5) | 34-69 |
| National Tournament Round 2 |
| Mar. 24, 2019 | Round 129 | Michigan - Louisville (5) | 50-71 |
| National Tournament Round 3 |
| Mar. 29, 2019 | Round 130 | Oregon St. (11) - Louisville (5) | 44-61 |
| Quarter-Finals |
| Mar. 31, 2019 | Round 131 | Connecticut (2) - Louisville (5) | 80-73 |
